The day explores the foundations of the obesity pandemic, covering its definition, epidemiology, social determinants, and dietary contributors. Sessions highlight vulnerable populations, the role of ultraprocessed foods, and how diet composition shapes metabolic health.
| Time | Activity / Topic | Speaker / Presenter |
|---|---|---|
| 7:30 - 8:00 | Check-in | All participants |
| 8:00 - 8:15 | Opening | Licio Velloso |
| 8:15 - 8:45 | Is obesity a disease? | Licio Velloso |
| 8:45 - 9:45 | The traditional and new hypotheses behind obesity pandemic | Mario Saad |
| 9:45 - 10:45 | The main epidemiological triggers of obesity pandemic | Licio Velloso |
| 10:45 - 11:00 | Coffee break | |
| 11:00 - 12:00 | Current epidemiology of obesity and its complications | Bianca Pitito |
| 12:00 - 12:30 | From poverty to obesity | Dennys Cintra |
| 12:30 - 14:00 | Lunch | |
| 14:00 - 14:45 | Obesity and Nutritional Transition in Native Americans | Ana Paula Davel |
| 14:45 - 15:30 | Children and Adolescence | Bianca Pitito |
| 15:30 - 16:15 | Low Income Populations | Marina Norde |
| 16:15 - 16:30 | Coffee break | |
| 16:30 - 17:15 | Ultraprocessed foods | Marina Norde |
| 17:15 - 18:00 | Fat Components of Diet and Metabolic Health | Dennys Cintra |
| 18:00 | End |
This day focuses on developmental origins of health and disease, from pregnancy and fetal programming to breastfeeding and epigenetics. Afternoon sessions examine molecular mechanisms—histones, micro‑RNAs, endocrine disruptors—and conclude with genetic phenotyping.
| Time | Activity / Topic | Speaker / Presenter |
|---|---|---|
| 8:00 - 8:45 | Exerkines Connecting the Muscle with Metabolic Health | Vitor Muñoz |
| 8:45 - 9:30 | Circadian Clocks and Insulin Sensitivity | Vitor Muñoz |
| 9:30 - 10:30 | Cardiovascular Risk Estimation: Limitations and Perspectives | Andrei Sposito |
| 10:30 - 10:40 | Coffee | |
| 10:40 - 11:30 | Metabolic Inflammation and Its Impact on Health | Licio A. Velloso |
| 11:30 - 12:20 | Hypothalamic cellular niche orchestration of immune-metabolic adaptation to nutritional stress | Natalia Mendes |
| 12:20 - 13:45 | Lunch | |
| 13:45 - 14:30 | Inflammation and Insulin Resistance | Pedro Vieira |
| 14:30 - 15:15 | Macrophages, Microglia and Other Cellular Components of Metabolic Inflammation | Pedro Vieira |
| 15:15 - 16:15 | MASLD | Claudia Pinto Marques Souza de Oliveira |
| 16:15 - 16:30 | Coffee | |
| 16:30 - 17:30 | GLP-1 Agonists: Beyond Diabetes and Obesity | Mario Saad |
| 17:30 | End |
The program examines energy balance and thermogenesis, emphasizing uncoupled respiration and brown adipose tissue. Genetics, sex differences, and metabolic phenotype variation are explored, ending with how biological sex shapes hypothalamic and metabolic function.
| Time | Activity / Topic | Speaker / Presenter |
|---|---|---|
| 8:00 - 9:00 | Hypothalamus | Licio Velloso |
| 9:00 - 10:00 | Effects of intracerebroventricular administration of irisin on the regulation of energy homeostasis in diet-induced obese mice | Helena Barbosa |
| 10:00 - 10:15 | Coffee | |
| 10:15 - 11:15 | GH and Other Hormones | Jose Donato Jr |
| 11:15 - 12:15 | The role of glial cells on the control of energy homeostasis | Lucila Elias |
| 12:15 - 13:15 | Lunch | |
| 13:15 - 14:15 | Other Gut Peptides that Control the Brain | Jose Donato Jr |
| 14:15 - 15:15 | Leptin Action in the Hypothalamic Control of Metabolism | Carol Elias |
| 15:15 - 15:30 | Coffee | |
| 15:30 - 16:15 | Hypothalamic cholinergic signalling: a new player in the control of energy balance | Márcio Torsoni |
| 16:15 - 17:15 | The Physiology and Pathology of GLP1 | Marcelo Miranda |
| 17:15 | End |
This day centers on neuroendocrine regulation of metabolism, covering the hypothalamus, leptin, hormonal systems, dopamine pathways, cannabinoids, and gut–brain peptides. It concludes with GLP‑1/GIP actions in the brainstem.
| Time | Activity / Topic | Speaker / Presenter |
|---|---|---|
| 8:00 - 8:45 | General Concepts of Energy Balance | Licio Velloso |
| 8:45 - 9:30 | Canonical Uncoupled Respiration | Luiz Osorio Leiria |
| 9:30 - 10:15 | Atypical Uncoupled Respiration | Carlos Sponton |
| 10:15 - 10:30 | Coffee | |
| 10:30 - 11:30 | Brown Adipose Tissue as an Endocrine Organ | Luiz Osorio Leiria |
| 11:30 - 12:30 | Brown Adipose Tissue - Human Studies | Milena Monfort Pires |
| 12:30 - 14:30 | Lunch | |
| 14:30 - 15:30 | Sexual Dimorphisms and Metabolic Disease - Clinical Studies | Ana Claudia Latronico |
| 15:30 - 16:30 | Biological Sex in the Intersection of Hypothalamic Function and Metabolic Health | Carol Elias |
| 16:30 - 16:45 | Coffee | |
| 16:45 - 17:30 | Abnormalities in Gluconeogenesis in Obesity | Gabriel Anhê |
| 17:30 | End |
Participants spend the day in scientific oral presentations, showcasing research across obesity and metabolism. A session on FAPESP funding opportunities supports researchers seeking grants.
| Time | Activity / Topic | Speaker / Presenter |
|---|---|---|
| 8:30 - 9:00 | FAPESP grant opportunities | Licio Velloso |
| 9:00 - 9:10 | Oral Presentation #1 (Metabolically healthy obesity in women is characterized by preserved brown adipose tissue activity despite blunted cold-induced thermogenesis) | Isabela Solar |
| 9:10 - 9:20 | Oral Presentation #2 (Brown Adipose Tissue and lipodystrophy) | Maria Eduarda Martelli |
| 9:20 - 9:30 | Oral Presentation #3 (Control of thermogenesis and metabolic homeostasis by a subpopulation of sympathetic-sensory innervation) | João Alves |
| 9:30 - 9:40 | Q&A | |
| 9:40 - 10:00 | Oral Presentation #4 (Exercise-induced extracellular vesicles mitigate obesity phenotypes and improve insulin sensitivity in HFD-fed mice) | Júlia Marinatto |
| 10:00 - 10:10 | Oral Presentation #5 (TLC-1180 Mitigates Cognitive Decline in Diet-Induced Obese (DIO) Mice) | Rafael Gaspar |
| 10:10 - 10:20 | Oral Presentation #6 (Development of a 3D Human Skin Model to Study Diabetes-Associated Alterations) | Monielle Leal |
| 10:20 - 10:30 | Q&A | |
| 10:30 - 10:50 | Coffee | |
| 10:50 - 11:00 | Oral Presentation #7 (Growth hormone receptor in Phox2b-expressing neurons regulates gut motility and feeding pattern after food restriction) | Guilherme Nascimento |
| 11:00 - 11:45 | Mechanisms by which the fasting mimicking diets promote metabolic benefits | Maura Fanti |
| 11:45 - 13:15 | Lunch | |
| 13:15 - 13:25 | Oral Presentation #8 (Overweight and obesity and their association with intestinal permeability, usual dietary intake, and serum retinol concentrations) | Maria Clara Carvalho |
| 13:25 - 13:35 | Oral Presentation #9 (Fetal Programming of the Reward System by Maternal High-Fat Diet Consumption: Modulation by Melatonin Receptor Agonist) | Yuri Conceição |
| 13:35 - 13:45 | Oral Presentation #10 (Impact of Maternal High-Fat Diet–Induced Obesity on Behavioral and Metabolic Outcomes in Female Dams and Adult Offspring) | Tamires Stivanin |
| 13:45 - 13:55 | Q&A | |
| 14:00 - 15:00 | Regulation of Iron distribution in white adipose tissue | Hernandez Moura |
| 15:00 - 15:10 | Oral Presentation #11 (EFFECTS OF MULTIDISCIPLINARY INTERVENTION THROUGH TELEMEDICINE ON SLEEP QUALITY IN WOMEN LIVING WITH OVERWEIGHT OR OBESITY AND INFERTILITY: PRELIMINARY RESULTS) | Laura Nunes |
| 15:10 - 15:20 | Oral Presentation #12 (Invesgating the metabolic and cognitive disfunctions between a mouse model of surgical and ovary intact menopause) | Celine Camon |
| 15:20 - 15:30 | Oral Presentation #13 (CENTRAL AND PERIPHERAL TRANSCRIPTIONAL ADAPTATIONS PRECEDE ADIPOSE IMMUNE REMODELING IN RESPONSE TO INCRETIN-BASED THERAPIES) | Sónia Norberto |
| 15:30 - 15:40 | Q&A | |
| 15:40 - 16:00 | Coffee | |
| 16:00 - 16:10 | Oral Presentation #14 (Investigating the Sex Hormone-Mediated Role of Resident Tissue Macrophages in Type 2 Diabetes) | Jia Zhao |
| 16:10 - 16:20 | Oral Presentation #15 (Investigating determinants of resident tissue macrophage heterogeneity) | Anika Hutton |
| 16:20 - 16:30 | Q&A | |
| 16:30 - 17:30 | Career development in biomedical sciences - From Brasília to MIT | Hernandez Moura |
| 17:30 | End |
Poster presentations and cultural activities.
| Time | Acitivity/Topic | Speaker |
|---|---|---|
| 9:00 - 12:00 | Poster Presentation | |
| 12:00 | Lunch | |
| 17:00 - 21:00 | Happy hour and cultural activity (CPV) |
The focus shifts to muscle–metabolism communication, inflammation, and immune involvement in metabolic disease. Sessions address insulin resistance, macrophage and microglial roles, MAFLD, and gut microbiota interactions.
| Time | Activity / Topic | Speaker / Presenter |
|---|---|---|
| 8:00 - 9:00 | Food, Inflammation and Gut Microbiota | Marco Vinolo |
| 9:00 - 10:00 | General View of Gut Microbiota + Interventions that Modify Gut Microbiota | Mario Saad |
| 10:00 - 10:15 | Coffee | |
| 10:15 - 11:15 | Mechanisms of GLP1 analogs actions in the gut | Vinícius Oliveira |
| 11:15 - 12:00 | Glucagon Secretion | Ivan Quesada |
| 12:00 - 13:30 | Lunch | |
| 13:30 - 14:30 | Insulin Secretion | Ivan Quesada |
| 14:30 - 15:15 | Metabolism-disrupting agents | Angel Nadal |
| 15:15 - 16:15 | From Insulin Resistance to Diabetes - the Long and Winding Road | Bruno Geloneze |
| 16:15 - 16:30 | Coffee | |
| 16:30 - 17:10 | Wound Healing | Carlos Poblete |
| 17:10 - 18:00 | The longevity impact of methionine-supplemented diet | Maura Fanti |
| 18:00 | End |
This day explores gut–pancreas–metabolism connections, including microbiota interventions, insulin and glucagon secretion, endocrine disruptors, and complications such as kidney disease and wound healing. It ends with obesity framed through a One Health perspective.
| Time | Activity / Topic | Speaker / Presenter |
|---|---|---|
| 8:00 - 8:45 | Nutrition during Pregnancy | Maria Laura Costa |
| 8:45 - 9:45 | Fetus Programming | Adriana Torsoni |
| 9:45 - 10:30 | Placental Abnormalities in Maternal Obesity | Maria Laura Costa |
| 10:30 - 10:45 | Coffee | |
| 10:45 - 11:30 | Breastfeeding and Its Impact on the Metabolic Health of Offspring | Bruna Bombassaro |
| 11:30 - 12:30 | From Darwin to Lamarck - the Birth of Epigenetics | Marcelo Mori |
| 12:30 - 14:00 | Lunch | |
| 14:00 - 15:00 | DNA modification by epigenetic mechanisms | Adriana Torsoni |
| 15:00 - 15:45 | Histone Modifications by Epigenetic Mechanisms | Marcelo Mori |
| 15:45 - 16:00 | Coffee | |
| 16:00 - 16:45 | Micro-RNAs | Marcelo Mori |
| 16:45 - 17:45 | How Endocrine Disruptors damage the Pancreatic Islets | Angel Nadal |
| 17:45 | End |
A full day of hands‑on workshops allows participants to deepen practical skills and applied knowledge across obesity‑related topics.
| Time | Activity / Topic | Speaker / Presenter |
|---|---|---|
| 9:00 - 12:00 | Groups 1 and 2 (55 participants) | |
| 14:00 - 17:00 | Groups 3 and 4 (55 participants) | |
| Workshops: Culinary medicine, the “Desrotulando” app, DEXA (dual-energy X-ray absorptiometry), and a BAT thermographic camera |
The program turns to clinical and lifestyle interventions—healthy cooking, dietary guidelines, cardiometabolic diseases, GLP‑1–based therapies, emerging drugs, and bariatric surgery—closing with future pharmacological opportunities.
| Time | Activity / Topic | Speaker / Presenter |
|---|---|---|
| 8:00 - 8:10 | Oral Presentation #16 (Physiological, nutritional, and behavioral effects of a weight-neutral lifestyle intervention versus a weight-centered lifestyle intervention in the treatment of overweight and obesity.) | Heloisa Castanheira |
| 8:10 - 8:20 | Oral Presentation #17 (Effects of a Resistance Exercise Training Program on Skeletal Muscle Quality, Immune Response, and Physical Performance in Older Women with Normal Weight versus Obesity) | Nicolás Seguel |
| 8:20 - 8:30 | Oral Presentation #18 (Institutional and governance determinants of obesity-related policy implementation in primary health care: a machine learning analysis of Brazilian health systems) | Camila Mazzeti |
| 8:30 - 8:40 | Q&A | |
| 8:40 - 8:50 | Oral Presentation #19 (ESCOLARISANO: A School-Based Healthy Lifestyle Intervention for Cardiometabolic Health in Vulnerable Mexican Children) | Ana Maria Mexía |
| 8:50 - 9:00 | Oral Presentation #20 (Long-Term Weight Regain, Conversion Rates, and Complications After Laparoscopic Rouxen-Y Gastric Bypass Versus Sleeve Gastrectomy: A Systematic Review and Meta-Analysis of Comparative Studies With ≥10-Year Follow-Up) | Camila Hermosilla |
| 9:00 - 9:10 | Oral Presentation #21 (Evaluation of the Effects of Cyclic Semaglutide Treatment in Diet-Induced Obese C57BL/6J Mice) | Nayra Oliveira |
| 9:10 - 9:20 | Q&A | |
| 9:20 - 9:30 | Oral Presentation #22 (Life-Course Trajectories of Nutritional Status and Movement Behaviors: Implications for Obesity-Related Inflammation and Male Reproductive Function) | Pamela Romo |
| 9:30 - 9:40 | Oral Presentation #23 (Preconception maternal nutritional status, maternal gut microbiota during pregnancy, and mode of delivery as determinants of early-life gut microbiota and metabolic risk programming in term newborns: a prospective cohort study) | Paulina Aguiar |
| 9:40 - 9:50 | Q&A | |
| 09:50 - 10: 20 | Coffee | |
| 10:20 - 10:30 | Oral Presentation #25 (Effect of Antidiabetic Drugs on Papillary Thyroid Carcinoma: An In Vitro Study) | Mariana Gonçalves |
| 10:30 - 10:40 | Oral Presentation #26 (Effects of Galectin-3 Inhibition in a Model of Hepatocellular Carcinoma Associated with Metabolic Dysfunction) | Anne Santos |
| 10:40 - 10:50 | Oral Presentation #27 (ROLE OF ADIPOSE TISSUE-DERIVED EXTRACELLULAR VESICLES IN REDOX BALANCE AND MALIGNANCY OF MDA-MB-231 BREAST CANCER CELLS) | Victor Franco |
| 10:50 - 11:00 | Q&A | |
| 11:00 - 11:10 | Oral Presentation #28 (Flattening Circadian Glucocorticoid Rhythms Reprograms Adipose Tissue Biology and Glucose Homeostasis in Diet-Induced Obese Mice | Lucas Saavedra |
| 11:10 - 11:20 | Oral Presentation #29 (THE ROLE OF ADIPOSE TISSUE DERIVED MICRORNAS IN OBESITY AND LIPODYSTROPHY-INDUCED NON-ALCOHOLIC FATTY LIVER DISEASE) | Giovanna dos Santos |
| 11:20 - 11:30 | Q&A | |
| 11:30 - 13:00 | Lunch | |
| 13:00 - 13:10 | Oral Presentation #30 (Silencing of PCSK9 through miRNAs delivered by exosomes: implications for the reduction of atherosclerosis) | Tamires Zanotto |
| 13:10 - 13:20 | Oral Presentation #31 (Adiposity and Liver Fibrosis in Metabolic Dysfunction-Associated Steatotic Liver Disease: Association Between Visceral Fat Distribution and Fibrosis.) | Clara Marrucho |
| 13:20 - 13:30 | Oral Presentation #32 (Differential expression of miRNAs in gestational diabetes: an approach to developing risk prediction models) | Ana Borrero |
| 13:30 - 13:40 | Oral Presentation #33 (Uncovering the mechanisms of calorie restriction-induced insulin sensitivity: the potential role of adipose tissue-derived miRNAs) | Cristiane dos Santos |
| 13:40 - 13:50 | Q&A | |
| 13:50 - 14:00 | Oral Presentation #34 (INVESTIGATION OF THE PROPERTIES OF MEDIUM-CHAIN N-ACYLGLYCINES IN THE MODULATION OF ENERGY METABOLISM UNDER CALORIC RESTRICTION CONDITIONS) | Julya Nascimento |
| 14:00 - 14:10 | Oral Presentation #35 (Tudca and aging: metabolic and muscular effects) | Marina Carvalho |
| 14:10 - 14:20 | Oral Presentation #36 [Molecular and functional characterization of endocrine-metabolic in the double burden of malnutrition: Potential mechanisms of action of Tauroursodeoxycholic Acid (TUDCA)] | Kênia Oliveira |
| 14:20 - 14:30 | Q&A | |
| 14:30 - 14:40 | Oral Presentation #37 (iNKT Cells Role in Adipose Tissue Metabolism and Hepa c Homeostasis During Intermient Fasting) | Raisa Santos |
| 14:40 - 14:50 | Oral Presentation #38 (Hepatic stellate cell–specific eNOS expression in the modulation of fibrogenic pathways in the liver) | Jaddy Guijo |
| 14:50 - 15:00 | Oral Presentation #39 (Hepatic noradrenergic innervation induces autophagy and fuels gluconeogenesis and ketogenesis via calcium pathways under cold stress) | Henrique Morgan |
| 15:00 - 15:10 | Q&A | |
| 15:10 - 15:30 | Coffee | |
| 15:30 - 15:40 | Oral Presentation #40 (Hypothalamic de novo ceramide synthesis drives central resistin-induced neuroinflammation and glucose intolerance) | Jeanne Guitton |
| 15:40 - 15:50 | Oral Presentation #41 (Glucocorticoid receptor in AgRP neurons regulates adaptive feeding and protects against diet-induced metabolic dysfunction in male mice) | Juliana Gebenlian |
| 15:50 - 16:00 | Oral Presentation #42 (ROLE OF AGRP AND POMC NEURONS AND MESOLIMBIC PATHWAYS ON THE CONTROL OF FOOD INTAKE IN NEONATAL NUTRITIONAL PROGRAMMING) | Henrique Vieira |
| 16:00 - 16:10 | Q&A | |
| 16:10 | End |
The final day features another round of oral presentations, offering a platform for diverse research contributions before the event concludes.
| Time | Activity / Topic | Speaker / Presenter |
|---|---|---|
| 8:00 - 9:00 | Principles of Health Cooking | Caroline Capitani |
| 9:00 - 10:00 | New Strategies for Dietary Guidelines | Marina Norde |
| 10:00 - 10:15 | Coffee | |
| 10:15 - 11:15 | Hypertension | Wilson Nadruz |
| 11:15 - 12:15 | Historical aspects of biomedical research - how did we get here? | Licio Velloso |
| 12:15 - 14:00 | Lunch | |
| 14:00 - 14:45 | The Problems of the Old Drugs | Bruno Geloneze |
| 14:45 - 15:30 | Mono and Dual GLP1 Agonists | Bruno Geloneze |
| 15:30 - 16:15 | What is in the Pipeline? | Bruno Geloneze |
| 16:15 - 16:30 | Coffee | |
| 16:30 - 17:15 | General view of Bariatric Surgery in Severe Obesity | Everton Cazzo |
| 17:15 - 18:00 | The window of Opportunities for New Pharmacological Approaches | Licio Velloso |
| 18:00 | Closing of SPSAS Obesity | Licio Velloso |